Pregnenolone (Preneno-Max), a sustained-release, 24-hour brain enhancement steroid.
Pregnenolone is the grand precursor of most if not all brain steroids and messengers. Pregnenolone improves memory; whereas progesterone decreases anxiety. The brain effects of pregnenolone include modulation of brain receptors and their effects on seizure, anxiety, depression, memory, and learning processes. (Flood et al., 1992; Meyer et al., 2002).
Mechanism in the Brain: Pregnenolone results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that increases neurogenesis, decreases brain cell apoptosis (natural cell destruction) and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and significantly increases GABA receptor responses. (Neuroscience. 2011 Sep 15;191:78-90. doi: 10.1016/j. neuroscience.2011.06.076. Epub 2011 Jul 1.)
Studies in lab animals demonstrated that pregnenolone and DHEA displayed memory-enhancing properties in aged rodents.
Veterans with chronic lower back pain participated in a randomized, double-blind placebo-controlled clinical trial using pregnenolone for 42 months. They were veterans from 18 to 65 years with chronic lower back pain. Results showed that they reported significant reductions in lower back pain relative to those randomized to placebo. (2020 Mar 2;3(3):e200287.doi: 10.1001/jamanetworkopen.2020.0287.)
Pregnenolone protected mice against inflammatory bone destruction in vivo by suppressing osteoclasts that breakdown old bone cells. (Front. Pharmacol., 2020 Mar 27; 11:360. doi: 10.3389/fphar.2020.00360. eCollection 2020.)
Formulation and Dosage
It is formulated in a lipid matrix to bypass the liver and micronized to a particle size of fewer than 50 microns for optimal absorption. This product is soy free and sourced from wild yams that have not been irradiated nor ethylene-oxide treated.
Suggested Use: As a dietary supplement, for women ½ to 1 tablet per day; for men 1 tablet daily; or as directed by a healthcare professional.
1 scored tablet
Servings per container
Amount per serving:
Other ingredients: Microcrystalline cellulose, Micosolle®, vegetable oil, vegetable wax, Cab-o-sil®, magnesium stearate, vitamin E.
Variations in product color may occur. Keep in a cool, dry place, tightly capped.
WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT OR NURSING. Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. KEEP OUT OF REACH OF CHILDREN. Do not use if you are at risk for or have been diagnosed as having any type of hormonal cancer, such as prostate or breast cancer.
*This statement has not been evaluated by the U.S. Food and Drug Administration. The product is not intended to diagnose, treat, cure, or prevent any disease.
Pregnenolone (Pregneno-Max) is available in 50mg SUSTAINED-RELEASE tablets, 60 tabs per bottle for the reduced price of $39.95 per bottle.