“The reason for time is so that everything doesn’t happen at once!” by Albert Einstein.
Interestingly, Mother Nature employs a ‘Pulsing Schedule’ in our Endocrine glands. Taking hormones and nutrients only once daily may not promote optimal health. Ideally, we should consume them many times daily because Mother Nature employs this pulsing schedule in our endocrine glands. In nature, many hormones are repeatedly pulsed from endocrine glands as our bodies’ physiologic demands wax and wane. This waxing and waning is especially important in the case of exercise. For example, the pituitary gland pulses HGH about six to twelve times a day. Copying Mother Nature means that, ideally, patients should apply a gel or inject micro amounts of HGH together with its vital metabolite, IGF-1 (SermMax & ReleasingMax), many times daily. Optimally, I recommend 0.01mg HGH plus the same amount of IGF-1 used BID---in other words, used mornings and evenings.
How to Use Hormones and Peptides to Enhance your Workouts.
For optimal exercise performance, I like to use a third or fourth hormone dose after normal exercise for better recovery. Correcting HGH combined with IGF-1, testosterone, follistatin, and a protein diet results in increased muscle mass, strength, hard buttocks, and firm back muscles usually seen optimally in young athletes-- more on this subject later in my lecture. It is well established in more than 240 publications that tiny physiologic doses of IGF-1 enhances body firmness, memory, physical stamina, and especially brain speed.
Hormone Correction during Normal Exercise
A second pulsed hormone of interest is testosterone. The testis and other glands pulse testosterone in a similar manner as described previously. Indeed, both testosterone and HGH pulse in high output when we exercise normally and produce lactic acid. Subsequently, lactic acid induces endocrine gland pulses -- a fact often overlooked by many people. For best effect during exercise, copy nature and consume only physiologic amounts of five combined hormones, namely testosterone, hGH, IGF-1, follistatin (FollistatinMax), and Armour Thyroid. In my opinion, these five perform well, and especially synergistically, during periods of normal exercise. Testosterone acts even as an efficient HGH pituitary releaser ---without the need for other secretagogues. Follistatin prevents break down of muscle tissue. Unlike synthetic drugs, these natural and bio-identical hormones do not act as one trick ponies. That is to say, they work best when synergistically combined with one another for optimal effect. If we are over the age of 50 years and have multiple hormone deficiencies, we will definitely need one or more extra doses of them when we normally engage in regular exercise.
Mesotherapy Facial Treatment.
Mesotherapy Facial Treatment is used by dermatologists in this slide to reduce the signs of facial aging by enhancing facial radiance and smoothness. This treatment stimulates the skin to produce collagen and elastin. Also, it activates stem cells and draws them to the facial skin in order to repair scars and fine wrinkles. Interestingly, this wonderful technique further enhances the skin when the previously-mentioned hormones, plus estradiol, plus retinol are applied topically. Furthermore, I have discovered personally that IGF-1 and growth hormone dissolved in hydrogel is an excellent non-conventional anesthetic when applied topically an hour before mesotherapy treatment.
Better Appreciation of Pharmacokinetics and Steady-State Concentrations.
If we truly appreciate the pharmacokinetics and half lives of hormones and nutrients, it would compel us to copy nature and consume them at least two to three times daily, or alternatively, consume them in time-release capsules or liposomal liquids or gels. For example in men, DHEA deficiencies (DHEA-Max) should be remedied by once daily use of DHEA liposomal gel. Both women and men should avoid consumption of 50mg DHEA taken bolus as advocated by some. This bolus dose has a half-life of only 15 to 38 minutes, and thus, after several hours, a patient may well become deficient again. In men, DHEA blood levels up to an optimal (1) 400 to 800 μg/dl (or DHEA-S 250 to 500 μg/dl) may be achieved by using time-released liposomal gel without appreciable rise in E2 and relatively stable SHBG. An important last example is nature's own method of a time-release hormone, namely Armour® Thyroid. Armour Thyroid is extracted from pig thyroids and acetone-desiccated to a dry powder. Natural bio-identical pig thyroid contains the most active of thyroid analogs, namely thyroxin or T3 that is bound to globulin, thus forming thyroglobulin. The bound thyroglobulin slowly releases T3 over many days, whereas synthetic T3 is quickly metabolized, especially during heavy exercise. Indeed, thyroglobulin has a half-life of 65 hours. Therefore, Mother Nature herself has designed a long acting, steady state, time-release hormone critical to health and longevity. Natural thyroid rapidly eliminates the signs and symptoms of hypothyroidism such as cell proliferation, ptosis, and myxedema.According to experts, thyroid deficiency increases mortality by about 43%! It is a significant predictor of all-cause mortality. Thus, for optimal health, copy nature and choose time-released desiccated pig thyroid.
Reversing The Aging Process: How Free Radicals Damage Us, and Hormones and Nutrients Repair Us
First on my bucket list is the quenching or rendering harmless of free radicals and related reactive oxygen. Many decades ago, my free-radical research brought me to the conclusion that free radicals and reactive oxygens are extremely deleterious to our health. Please observe carefully this photo. During only an eleven-month exercise period, the physiques of these six individuals improved enormously. Observe their improved physiques. However, notice how their heads, faces and hair color have deteriorated SIGNIFICANTLY during only eleven months. Indeed, their heads have aged at least 5 years in the space of less than one year! For example, observe the greying of their hair and the wrinkling and aging of their facial skin. Allow me to explain further why this acceleration in aging has occurred. Since 1972, I have studied the methods and theories of professor Denham Harman, and I came to the conclusion that OXIDATION is DANGEROUS TO OUR HEALTH AND LONGEVITY. Permit me to explain further in great detail. Biologists tell us that at some point in the evolution of our planet, blue-green algae came into being and free oxygen became available. This development allowed an increased energy yield from food by aerobic metabolism. A comparison of aerobic and anaerobic organisms reveals that aerobic have found it essential to develop Multiple Lines of Defense that prevent damaging oxidative reactions. On the other hand, anaerobic organisms find oxygen lethal because they lack all defenses.
What is Molecular Oxygen and How Might it Affect Our Health?
To the physicist, molecular oxygen can be lethal for reasons of its triplet ground state, electron spins, and its conservation of angular momentum. To the non-physicist, this means that molecular oxygen can easily share its electrons, and we often call this process oxidation. Interestingly, aerobic organisms including humans must have multiple lines of defense against lethal oxygen. Oxygen is toxic and lethal, and it requires multiple lines of defense to protect against oxidative damages and aging, especially inside our cells and within our mitochondrial respiratory chain. Note that this form of mammalian oxidation involves the controlled burning of oxygen combined with fats and sugars in our mitochondria.
Controlled Mitochondrial Burning
First as determined by research in Sweden years ago, this controlled burning process is 92 to 96 percent efficient in human mitochondria. The remaining 4 to 8% results in a 24/7 unstoppable free-radical cascade that can damage tissue, telomeres, and DNA. To minimize this cascade, nutrients such as CoQ10 or ubiquinol should be consumed because they help to facilitate better electron transport in the respiratory chain of mitochondria. If this cascade is not minimized, our skin and internal organs accumulate lipofuscin or age pigment containing oxidized lipids.
Why Are Free Radicals from Mitochondrial Oxidation Toxic?
Unfortunately, the remaining 4 to 8 percent radical cascade converts to toxic free radicals and reactive oxygens such as hydrogen peroxide, superoxide, lipid peroxides, singlet oxygen, and, most dangerous of all, the hydroxyl radical (symbol •OH ). This latter dangerous radical is also generated outside our bodies when radiation hits our cells and damages our DNA and its telomeres. And, guess what, our bodies experience approximately 7,000 radical ‘hits’ daily to our DNA. A poignant example of the incredible destructive power of hydroxyl radicals has been seen in the nuclear explosions of Hiroshima and Nagasaki that occurred at the end of WW2. In the survivors, hydroxyl radicals damaged their DNA and oxidized their bodies in nanoseconds! Those survivors with good hormone and stem-cell repair systems were able to rebuild and regenerate their bodies, their telomeres, and their DNA. Furthermore today, over 75 years later, survivors that I know personally as patients are healthy and living vibrant lives during their advanced senior years due to their bodies natural healing stem cells supported by growth promoters such as IGF-1, HGH (SermMax & ReleasingMax), and 7 other related growth enhancers.
Why Hydroxyl Radicals Are One of the Most Toxic Substances on the Planet
Hydroxyl radicals are definitely one of the most dangerous substances for humans on the planet with toxicity thousands of times greater than arsenic, cyanide, botulism, and many other toxins. And guess what: we have no natural defenses against hydroxyl radicals because their lifespan is measured in nanoseconds. This extremely short lifespan means damage to living cells is done almost instantaneously and no known defense exists to interfere with this near-instant destructive force. In consequence, damage must be repaired, for example, with DNA repair enzymes, or we may develop cancer. This repair occurs with the help of hormones or nutrients such as the pseudo-hormone vitamin D3 that prevents many forms of cancer. Given a second example, consider a hydroxyl radical attack upon unsaturated fatty acids. This attack generates huge amounts of lipid peroxides in chain reactions. In Sweden at the Department of Medical Cell Biology, Biomedicum, I have measured this chain reaction in vivo and non-invasively in human volunteers and found that people who used interveneous drugs such as methamphetamine exhibit the fastest increase of lipid peroxides. These chain reactions give rise to tissue damages that can only be prevented by a termination of these chain reactions using antioxidants or free-radical scavengers. If this chain reaction is not terminated, massive accumulation of age pigment or lipofuscin occurs. Examples of lipofuscin massive accumulation are found in Batten’s disease and Alzheimer’s disease. Second, the oldest living population in the world lives in Okinawa, Japan. Harvard-trained professor Craig Wilcox discovered that 100-year-old Okinawans have half as much lipid peroxides as 70-year-old North Americans. Consequently, lipid peroxides are important to longevity.
What are Our Four Lines of Defense Against Reactive Oxygens and Radicals?
During the 1980s, my research firmly established that human mitochondria are only 92 to 96 percent efficient, and, we all have four lines of defense to render reactive oxygens and free radicals harmless. First Line of Defense. I call our first line of defense SOD, or superoxide dismutase. In a long series of reactions, SOD renders harmless the superoxide anion radical (symbol O 2•- ) to ordinary water and oxygen. Interestingly to those who exercise, the activity of SOD DOUBLES by exercising daily for at least an hour. However, very heavy aerobic exercise will not increase this doubling. The SOD enzyme is dependent upon trace amounts in our diet of the transition metals manganese, zinc, and copper. Molecular chemists tell us that these transition metals have long d-orbitals extending far out into molecular space. These d-orbitals easily release and accept electrons that are passed on to other d-orbitals in a bucket brigade fashion. Indeed, this is how electricity moves along a copper wire. And now I would like to present an important theme to my lecture concerning very heavy aerobic exercise,
People Engaged In Very Heavy Aerobic Exercise Generate Enormous Cascades Of Free Radicals That Escape the SOD Line of Defense
Unfortunately, very heavy aerobic exercise generates free radicals EIGHT TIMES, I say again 8 times, in excess of what the SOD first line of defense can deactivate and render harmless! An 8-times excess escapes the SOD enzyme and causes damages to living tissue and DNA.
A free-radical pathology experiment performed at UpJohn-Pharmacia in Sweden by professor Karl Arforrs. Superoxide was injected into the bloodstream of hamsters, and ischemic arterial damage resulted. This induced ischemia was totally reversed when strong antioxidants such as glutathione were subsequently injected into damaged arteries. This demonstrates the damaging effects of free radicals in arteries. Experiments in animals have revealed that the powerful superoxide anion radical causes arterial ischemic damage. Note that these arterial damages are what we have observed in people engaged in very heavy aerobic exercise as revealed in a previous slide.
Our Second Line of Defense.
Our second line of defense is what I call membrane-bound vitamins E or tocopherols. These antioxidants further eliminate some reactive oxygens that have escaped the first line of defense. However, this second line of defense is highly limited because the membranes of our cells and mitochondria cannot contain more than 2 percent vitamin E molecules by volume. On the bright side, recent research has indicated that a potent vitamin-E analog called tocotrienol concentrates in the membranes of endothelial cells. In rodent experiments, 40 % of mice receiving tocotrienol survived a lethal dose of hydroxyl-radical-type radiation versus 100 percent of control mice that died. Second, in human clinical studies, tocotrienols are known to significantly reduce incidence of stroke and loss of connectivity between different areas of the brain. Third, tocotrienols work against inflammation especially when combined with other antioxidants. Last, one significant anti-inflammatory effect of tocotrienols is a reduction of arterial stiffness.
Our Third Line of Defense.
Our third line of defense against the toxic byproducts of the mitochondrial respiratory chain are the enzymes glutathione peroxidase and catalase (ACF 228). With the help of transition metals, selenium and iron, they reduce hydrogen peroxide, symbol H2O2, to ordinary water and oxygen.
What is Hydrogen Peroxide?
Contrary to what many people believe, hydrogen peroxide is a weak oxidant, I repeat, a weak oxidant and not a free radical! I cannot emphasize this point enough because many people continue to believe otherwise. Hairdressers routinely use hydrogen peroxide to bleach hair. If we put a few drops of drugstore hydrogen peroxide on a finger, it will temporarily discolor the skin, rendering it a sickly white color. It is important to note that our catalase-and-glutathione-peroxidase line of defense deteriorates as we age, and thus, our ability to convert hydrogen peroxide to water and oxygen is progressively impaired. As a result, research has demonstrated that increasing amounts of hydrogen peroxide causes the greying and whitening of our hair and the partial loss of pigment in our skin during aging. I have often observed these effects in senior citizens. However, no correlation exists between longevity and hydrogen peroxide because again, it is a weak oxidant.
Our Fourth Line of Defense. What is the connection between the free-radical scavenger, Glutathione and Hormones IGF-1 and HGH?
Our fourth line of defense is the ubiquitous and powerful antioxidant glutathione. According to recent research, our bodies only produce sufficient antioxidants such as glutathione by maintaining youthful levels of powerful hormones such as IGF-1 and HGH (SermMax & Releasing-Max). In fact, a Positive Linear Relationship Exists in vivo Between IGF-1 and Glutathione Concentrations! For example, according to Higashi and colleagues from 2013 quote “The observed antioxidant effect of IGF-1 may contribute to maintaining vascular integrity by counteracting oxidative stress, thereby limiting atherosclerosis development.” Second, scientists Brown-Borg and colleagues from 2005 stated “The current results support a role for growth hormone in the regulation of antioxidant defense and ultimately, lifespan in organisms with altered GH or IGF-1 signaling.” A third reference from 2007 “. . . . One major mechanism underlying the anti-atherogenic effect of IGF-1 could be an antioxidant effect targeting the endothelium and leading to decreases in aortic superoxide levels.”
During aging, we develop increasing and ongoing deficiencies of these two vital hormones as well as decreasing levels of many other essential hormones. In other words, in our youth we are drowning in a tsunami of hormones, but eventually in our senior years we are chasing the fumes of hormone deficiencies. Thus, these deficiencies cause a further deficiency of our fourth line of defense, namely glutathione. Unfortunately, we cannot supplement glutathione or these hormones with oral tablets or capsules because of poor gut absorptivity.
Further-more, I would now like to pose the question: Why Do We Need Large Amounts of Glutathione? Interestingly, our vital lung epithelial cells must maintain high concentrations of glutathione during aging, or we may develop asthma, chronic obstructive pulmonary disorder or COPD, or other lung problems. By high concentrations, I mean that our epithelial lung cells should maintain a normal gradient of 140:1---- that is to say, lung-cell glutathione versus bloodstream glutathione. Mother Nature has determined this 140:1 gradient. This extreme gradient renders harmless reactive oxygens and free radicals formed in our sensitive lung cells when we breathe daily kilograms of oxygen that convert to grams of radicals. Consequently, One May Ask:
Is it Dangerous to Breathe?
Our sensitive lung cells continuously absorb oxygen gas. In order to prevent oxidative tissue damage—think rusting iron or rancid nuts—we must prevent oxidative damage by generating large quantities of fresh glutathione daily. On the other hand, when asthma patients inhale corticosteroid sprays, these remedies increase epithelial cell metabolism and perhaps even increase glutathione somewhat. But after many years of revving up the system with corticosteroids, serious side effects often develop such as osteopenia and cataract. Therefore, these lung difficulties and side effects can be overcome by using more natural solutions. Instead of using synthetic inhalers, asthma and other lung disorders can often be successfully remedied by inhaling fine l-glutathione powder. Glutathione inhalation boosts and supports the 140:1 glutathione gradient. Also, it improves tissue bioavailability in our free-radical sensitive epithelial lung cells. This effect does not occur by ingesting oral tablets or capsules of glutathione with the exception, of course, of liposomal glutathione. In consequence, better gradient support and bioavailability relieves symptoms of asthma, COPD, and other lung difficulties Within a Few Minutes of Application. Glutathione is also significantly involved in Parkinson’s disease. In a 1999 study by professor Prasad and colleagues, they determined that the substantia nigra of Parkinson’s patients contained only half as much glutathione as patients without Parkinson’s.
What Happens with Deficiencies In Our Four Lines of Defense?
If there are deficiencies in the four lines of defense, our bodies naturally respond with inflammation. Inflammation is the underpinning of all age-related diseases, including cardiovascular and cerebrovascular diseases, diabetes and cancer. Inflammation is commonly measured with C-reactive protein, and it is visibly apparent as edema. Edema causes a puffy appearance, which is seen even in healthy and athletic people. You will observe that even though this actor and others are very muscular and athletic in their youth, they have eventually acquired edema due to inflammation and caused, in part, by unchecked free radicals and reactive oxygens that have run amok and damaged tissue. In other words, free radicals and reactive oxygens have escaped their four lines of defense, causing havoc and edema throughout their bodies. -----As stated by Dr. Barry Sears “To avoid aging, Inflammation must be turned off.”
Why are Free Radicals and Heavy Aerobic Exercise Dangerous to Health and Aging?
Free radicals are dangerous to one’s health, especially in the case of athletes engaging in very heavy aerobic exercise that uses daily kilograms of oxygen, which in turn, generate grams of deadly free radicals. To further explain, it is well established since the 70’s by doctors Harman, Fridovich, McCord, and others that very heavy exercise generates a superoxide-radical cascade eight times greater than our SOD defense can handle. Thus, the escaping radicals cause edema, DNA damage, and visible signs of aging. Furthermore, radical damages are especially apparent in high performance athletes. For example, consider all the athletes who live normal lifespans between 75 and 85 years and participated in relatively low-intensity aerobic sports such as tennis, or golfing. On the other hand, compare them to those who played very heavy aerobic sports and had shortened lifespans such as 4-time Olympic gold-metal winner Jesse Owens who died at the early age of 68! Others include Joe Louis, Sugar Ray Robinson, Jackie Robinson, and Babe Didrickson –- all of whom died prematurely from natural causes in their sixties or even younger. A good example of this phenomenon is the star baseball player Jackie Robinson who died at age 53. Another poignant example of this effect occurs in modern day India. According to professor Raj Sohal at Southern Methodist University, shortened lives are common in India where ordinary vegetarian laborers work very hard aerobically and die on average at age 55. On the other hand, overweight Indian moneylenders, who sit all day and count money, die on average at age 75 like many Westerners. Thus, heavy physical labor or heavy aerobic sports burns up a body. Make no mistake.
To enhance their bodies, these people practiced very heavy aerobic exercises without protecting themselves with effective free-radical scavengers – not weak vitamins such as ordinary vitamins C and E! Observe that the right-hand photos show significant improvements in body and muscle tone. However, their whitened hair and changed faces reveal rapid aging due to extensive free radical and cross-linking damages. Indeed in this slide, extreme exercise without effective free-radical protection has caused nasolabial folds and facial grooves such as periorbital rhytids, as well as whitening of the hair during a period of only 11 months! -----While we are focusing on athletes, allow me to diverge a bit and add some comments on the enhancement of athletic abilities during aging. During the years 1990 to 2004, some US athletes freely used hormones and supporting nutrients to slow their aging and enhance their sports abilities. In particular, US baseball players extended their participation in baseball from their peak years of 26 to 30 to their late thirties or even early forties. They did this through hormone corrective therapy that was not strictly forbidden during the 14-year period from 1990 to 2004. For example, Barry Bonds hit 258 home runs in his five sessions between ages 35 and 39 years –an average of 51 home runs per year. Roger Clemens led the National League in earned-run average at age 42! Thanks to the enhancing abilities of hormones, these athletes achieved a second wind with feats of athletic prowess never seen before or since!
In our youth we are drowning in a tsunami of hormones, but eventually in our senior years we are chasing the fumes of hormone deficiencies. We can correct these deficiencies with nasal sprays, topical creams, liposomal tablets, and ear-canal transdermal gels. They release pharmacokinetically the needed hormones through the skin and into the bloodstream in a gradual steady-state fashion. Consequently, these methods of hormone administration are often superior to bolus administration of oral tablets and capsules. Second, many of the most toxic substances for humans on the planet are generated either internally in our cells or externally by radiation. As we age, we naturally defend against these toxins with our cells’ four lines of defense. When these defenses fail, we develop problems of aging, such as edema, atherosclerosis, slowed brain speed, and breathing difficulties. To avoid aging, we need to boost our four lines of defense with corrective supplements. Furthermore, more efficient lines of defense encourage fewer radical damages and longer, healthier lifespans. As first established by Fridovich, McCord, professor Denham Harman and others, humans and other mammals seem to be endowed by Mother Nature with strong free-radical lines of defense. These defenses allow long lives in humans compared to most other animals. Fourth, as established in ancient China, Rome, and by Dr. Séquard in Paris 140 years ago, Mother Nature has endowed us with strong endocrine glands, hormones, and stem cells that effectively repair damages, but unfortunately, these glands decline dramatically in output during aging. Thus, to encourage youthful faces and shiny eyes, improve breathing, increased longevity, attain a better quality of life, enhance cognitive function, and augment physical strength and stamina, we should correct peptide and hormone deficiencies and supplement free-radical scavengers using mostly time-release remedies.