Advantages of Sermorelin and Other Growth Hormone Releasing Peptides for You and Your Patients

July 04, 2017

Advantages of Sermorelin and Other Growth Hormone Releasing Peptides for You and Your Patients

Past Longevity Experiments

In 1972, I first read about the wonderful research at the University of Nebraska by Professor Denham Harman, who demonstrated that mean life span in mice could be increased by 50 percent with the help of the antioxidant BHT. I was skeptical about this research, but when I repeated Prof. Harman’s experiment in my lab, I found that, indeed, mouse life span increased significantly. My control mice died at a mean average age of 24 months, and my BHT-fed mice were healthy and active at 36 months. Indeed, one BHT-fed mouse lived to the happy age of 60 months! My repeat experiments taught me not to rush to judgment and to keep an open mind—the hallmark of any good scientist.

In 2007, I repeated my process of skepticism when I heard lectures from doctors Mark Gordon and Richard Walker. They hypothesized that sermorelin and related growth hormone (GH)–releasing peptides would induce the pituitary gland to release its reservoir of growth hormone. In fact, I was damn skeptical and told my colleagues and close friends that it was a lot of hokum.

The Aging of Endocrine Glands

However, as time passed, I encountered colleagues and patients who had experienced anecdotal improvements in their own aging when using GH-releasing peptides. I tried to reason why, but all I could imagine was a deteriorated and shriveled pituitary gland severely damaged by the aging process. I reasoned that this same fate is also found in the thymus gland, which is active and healthy in teenagers, but shrinks to the size of a dried prune without metabolic activity in everyone over the age of 50. Only the pineal gland seems to retain some metabolic activity during aging, allowing it to secrete diminished amounts of melatonin and other peptides critical to sleep and the circadian rhythm (1).

Replacing or Reactivating Endocrine Glands

Again, I learned to cast aside old assumptions and prejudices and open my mind to the possibilities of slowed or reversed aging if the endocrine glands could be activated or reactivated. Then, in 1992, I learned of the experiments of Professor Walter Pierpaoli in Italy (1). Prof. Pierpaoli used microsurgery to replace an old pineal gland in an aged rat with the pineal gland of a young rat. The result was the rejuvenation of the old rat by increasing muscle motor activity. I then concluded that some aspects of aging could be reversed either by replacing endocrine glands or reactivating them.

In 2008, I asked Prof. Pierpaoli and Dr. Thierry Hertoghe if such experiments were plausible and could be repeated in aging humans. They both responded in the affirmative but with the caveat that modern first-world countries would consider such human experiments unethical. Subsequently, I abandoned thoughts of radical microsurgery, and sought other means to revitalize aging endocrine glands.

Trust Dr. Richard Walker and His Work with Extended Life Span

Enter Dr. Richard Walker.

After 20 years of research, he substantiated the proposition that in aging humans, the pituitary gland could be awakened from its slumber with the help of certain specific peptides (2). One such peptide is called sermorelin. Others are called GHRP-2 and GHRP-6. (GHRP stands for growth hormone-releasing peptide.) All three of these marvelous peptides encourage the natural release of human growth hormone from the pituitary. This process encourages repair throughout the body and brain—and increased repair means extended life span.

Experimental Endocrinology

I completed a series of experiments with sermorelin and GHRP-6 (ReleasePro) with the help of my dear friends and colleagues, doctors Russell Laudon, April Underwood, and John Henrickson, Jr. In preliminary experiments, I established a mean average baseline of 67 ng/ml of insulin growth factor one (IGF-1) in seniors who had an average age of 65 years. This baseline was consistent with people who are over the age of 50, and whom we often call seniors.

Subsequently, every day for 30 days, I used sermorelin nasal or sublingual spray or SermPro twice daily on the cohort group. After four hours of application, IGF-1 increased to a mean average of 177 ng/ml. This was a significant improvement over baseline. However, please keep in mind that a normal 20-something male produces a baseline between 300 and 350 ng/ml (3). Thus, the 177 average was about half that of young males.

Females produced similar values although baseline is lower.

Apparently, sermorelin helped to boost aging subjects’ IGF-1 only halfway to the exalted baseline of young males. A similar increase was achieved when GHRP-6 was sprayed sublingually or nasally (ReleasePro). ReleaseProalso induces the pituitary to release its supply of human growth hormone (HGH) as measured by the downstream metabolite IGF-1. My colleagues and I have done many experiments with these three releasing remedies during the last 10 years.

Important Longevity and Pituitary Work by Dr. Thierry Hertoghe

Enter Dr. Hertoghe.

Dr. Thierry Hertoghe of the Hertoghe School of Medicine, Brussels, Belgium, decided years ago to bypass our shrinking and failing pituitary glands and give our bodies a boost with exogenous hormones. As an alternative, he began injecting himself and his patients directly with a combination of IGF-1 and HGH. He announced his findings in a book titled The Hormone Handbook, Second Edition, in May 2010. In November of that year, Dr. Hertoghe lectured extensively in Nevada and elsewhere in the United States on the theme of subcutaneously injecting IGF-1 and HGH in a ratio of 5:2.

Recently, he has altered his lectures by encouraging his patients, my patients, and me to alleviate signs and symptoms of aging by injecting twice daily using a 1:1 ratio (0.05 mg of each twice daily). These vital injections increased IGF-1 from the peptide-induced baseline of 177 ng/ml to the young adult or 20-something baseline of approximately 300 to 350 ng/ml in males and 250 ng/ml in females (3).

 Reversing the Signs and Symptoms of Aging

 “Let hormones rescue you from the ravages of aging!”

Dr. Hertoghe and I found that the 1:1 ratio truly works to eliminate signs and symptoms of aging, including decreasing cardiac injection fraction; elevated blood pressure; and a deepening of the lines and wrinkles on the face, hands, and arms. Indeed, before using this 1:1 ratio, I was personally obliged to seek out dermatologists to routinely inject my face with Restylane®, Perlane®, Botox®, and Dysport®. These four substances are the standard remedies used by dermatologists to flatten facial lines damaged by growth hormone deficiency and to fill out sinking facial cavities lacking collagen.

As an alternative, a gel lotion (Dr. Hertoghe’s Formula) composed of Dr. Hertoghe’s 1:1 ratio should be used several times weekly and after mesotherapy treatments. Dr. Hertoghe often recommends mesotherapy and subsequent facial skin treatment combined with transdermal hormone gels.

GH and GH-Releasing Peptides Help Reverse Aging

I found that the four standard remedies used by dermatologists were no longer necessary when Dr. Hertoghe’s 1:1 ratio was injected twice daily. In addition, a patient should schedule a twice-weekly injection holiday. I often chose Wednesdays and Sundays as my injection holidays.

During these holidays, SermPro or ReleasePro should be used nasally twice daily (10 IU each dose) to naturally release stores of pituitary growth hormone. This twice-weekly change in remedies further enhances the healing and rejuvenating effects of HGH and IGF-1 without stressing or overloading their receptor sites. This stressing or overloading of hormone receptor sites is called tachyphylaxis. This means the tendency for hormone receptors to become desensitized and overstimulated by continuous use without taking any holidays.

The twice-weekly holidays also help improve cardiac function and the signs of aging of the skin organ. Indeed, both superficial and deep skin rhytids (wrinkles) flattened and disappeared after about three months of this holiday protocol. (However, an additional hormone, aldosterone or AldoPro™, is needed to flatten periorbital rhytids, commonly called “crow’s feet.” [3])


In conclusion, while we await the singularity revolution (age reversal through genetic reprogramming) of Dr. Ray Kurzweil, I strongly encourage everyone interested in optimal health and minimal aging to follow Dr. Hertoghe and me with these injections and peptide nasal or sublingual sprays. SermPro, ReleasePro, AldoPro, and Dr. Hertoghe’s Formula are available for purchase at reduced wholesale prices at www.naturalspro.com. Nasal application is preferred over sublingual use due to better bloodstream absorption in the nasal cavity. However, both methods of application are efficacious.


   1.   Pierpaoli, Walter, 2011, Melatonin Miracle: Nature’s Age-Reversing, Sex-Enhancing, Disease-Fighting hormone, Simon and Schuster, New York, NY.


  1. Walker, Richard, 2006, Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?, Clinical Interventions in Aging, 1(4), pp. 1-2.
  2. Hertoghe, Thierry, 2010, The Hormone Handbook, 2nd Edition, International Medical Books, Luxembourg.


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